期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

周期素激酶抑制剂P27与心血管疾病 被引量：2

Cyclin-dependent kinase inhibitor P27 and cardiovascular disease
下载PDF
导出
摘要 P2 7蛋白是一种细胞周期激酶抑制剂 ,通过抑制cyclin CDK复合物活性使细胞停滞于G1期。P2 7蛋白能显著抑制血管平滑肌细胞等增殖 。
作者 付燕燕 蒲淑萍 段昌柱
机构地区 重庆医科大学生物学教研室
出处 《国外医学（临床生物化学与检验学分册）》 2004年第6期522-523,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 周期素激酶抑制剂 P27蛋白 心血管疾病 治疗手段 心血管系统疾病 血管平滑肌细胞 动脉粥样硬化 细胞周期 增殖 复合物
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

  • 1许顶立,袁勇,刘伊丽,李祥平,张荣华,赖文岩,贾满盈.血管紧张素Ⅱ和血小板源生长因子对血管平滑肌和心肌细胞细胞周期素及P27蛋白的不同影响[J].中华医学杂志,1999,79(9):657-660. 被引量：25
  • 2Laufs U, Marra D, Node K, et al. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of P27(kip1). J Biol Chem, 1999, 274(31): 21926-21931.
  • 3Braun-Dullaeus RC, Ziegler A, Bohle RM, et al. Quantification of the cell-cycle inhibitors P27(kip1) and p21(Cip1) in human atherectomy specimens: primary stenosis versus restenosis. J Lab Clin Med, 2003, 141(3): 179-189.
  • 4Cospedal R, Lobo M, Zachary I. Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells. Biochem J, 1999, 342 ( P
  • 5Hayashi H, Ogawa N, Ishiwa N, et al. High cyclin E and low P27/kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients. Lung Cancer,2001,34(1): 59-65.
  • 6Lloyd RV, Erickson LA, Jin L, et al.P27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol, 1999, 154(2): 313-323.
  • 7Sherr CJ. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res, 2000, 60(14): 3689-3695.
  • 8De-Paola F, Vecci AM, Granato AM, et al. P27/kip1 expression in normal epithelium,benign and neoplastic breast lesions. J Pathol, 2002, 196(1): 26-31.
  • 9Migaldi M, Zunarelli E, Sgambato A, et al.P27kip1 expression and survival in NO gastric carcinoma. Pathol Res Pract, 2001, 197(4): 231-236.
  • 10Baba Y, Tsukuda M, Mochimatsu I, et al. Reduced expression of p16 and P27 proteins in nasopharyngeal carcinoma. Cancer Detect Prev, 2001, 25(5): 414-419.

二级参考文献19

  • 1袁勇,贾满盈,刘伊丽,吴赛珠,吴志坚,马立勤,冯力.血管紧张素Ⅱ对血管平滑肌细胞内游离钙的作用机制[J].中华心血管病杂志,1996,24(5):384-386. 被引量：13
  • 2Pollman MJ, Hall JL, Gibbons GH, et al. Determinants of vascular smooth muscle cell apoptosis after balloon angioplasty injury. Influence of redox state and cell phenotype. Circ Res, 1998,84:113-121.
  • 3Chang MW, Barr E, Seltzer J, et al. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form the retinoblastoma gene product. Science, 1995,267:518-522.
  • 4Chang MW, Barr E, Barton K, et al. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibior,p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest, 1995,96:2260-2268.
  • 5Yang ZY, Simari RD, Perkins ND, et al. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA, 1996,93:7905-7910.
  • 6Ophascharoensuk V, Fero ML, Hughes J, et al. The cyclin-dependent kinase inhibitor p27kip1 safeguards against inlammatory injury. Nat Med, 1998,4:575-580.
  • 7Feldman LJ, Sleg G. Optimal techenques for arterial gene transfer. Cardiovasc Res, 1997,35:391-394.
  • 8Ihling C,Technau K,Gross V,et al.Concordant upregulation of type IITGF-beta-receptor, the cyclin-dependent kinases inhibitor P27Kip1 and cyclin E in human atherosclerotic tissue: implications for lesion cellularity[].Atherosclerosis.1999
  • 9Pahan K,Sheikh FG,Namboodiri AM,et al.Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages[].The Journal of Clinical Investigation.1997
  • 10Nakagawa H,Mutoh T,Kumano T,et al.HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the phosphatidylinositol 3-kinase pathway[].FEBS Letters.1998

共引文献32

同被引文献28

  • 1盛瑞,顾振纶.超负荷心肌肥厚心肌细胞的凋亡和增殖[J].中国药理学通报,2005,21(5):531-535. 被引量：8
  • 2Asakawa M,Takano H,Uozumi H,et al.Peroxisome activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo[J].Circulation,2002,105(10):1240-1 246.
  • 3Devereux RB.Therapeutic option in minimizing left ventricular hypertrophy[J].Am Heart J,2000,139(1 Pt 2):S9-S14.
  • 4Anderson PG.Increased ischemic injury in hypertrophied rat[J].Circ Res,1990,67(6):943-946.
  • 5NakajimaH,Nakajima HO,Dembowsky K,et al.Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium[J].Circ Res,2006,98(1):141-148.
  • 6Ciarallo S,Subramaniam V,Hung W,et al.Altered p27(Kip1)phosphorylation,localization,and function in human epithelial cells resistant to transforming growth factor betamediat G(1)arrest J[J].Mol Cell Biol,2002,22(9):2 993-3002.
  • 7Urbanek K,Quaini F,Tasca G,et al.Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy[J].Prec Nat Acad Sci USA,2003,100(18):10 440-5.
  • 8liJM,Brooks G.Downregulation of cyclin dependent kinase inhibitors P21 and P27 in press overload hypertrophy[J].Am Physiol,1997,273:1 358-1 367.
  • 9Toyoshina H,Hunter T.P27,a novel inhibitionin of G1 cyclin-Cdk protein kinase activity,is related to P21 J[J].Cell,1994,78(1):67-74.
  • 10Lloyd RV,Erickson LA,jinL,et al.P27kip1;amultifunctional cyclin dependent kinase inhibitor with prognostic significance in human cancer[J].AM J Pathol,1999,154(2):313-323.

引证文献2

二级引证文献8

国外医学（临床生物化学与检验学分册）
2004年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部