摘要
目的探讨重组人生长激素(rhGH)对大面积烧伤患者细胞和体液免疫功能的影响。方法将24例大面积烧伤患者,随机分为rhGH治疗组和对照组。于切、削痂手术后1d(伤后7～10d)开始每天皮下注射rhGH0.2IU/kg;对照组注入0.9%氯化钠注射液2ml。两组患者疗程均为15d。动态滥测患者伤后第3、7、14、21、28d的血清免疫球蛋白IgG、IgA、IgM水平及CD4+、CD8+和淋巴细胞计数。结果IgA、CD4+和CD4+/CD8+值在伤后14、21和28d,治疗组明显高于对照组(P<0.05或0.01),而IgG、IgM、CD8+与淋巴细胞计数的差别无显著性意义(P>0.05)。结论治疗大面积烧伤病人时辅助使用rhGH,能增强机体的免疫功能。
Objective To investigate the effects of recombinant human growth hormone (rhGH) on the immuene function in severely burned patients. Methods Twenty-four burned patients were enrolled in the study and randomly divided into the rhGH group (0.2IU·kg-1·d-1) and control group (with normal saline). The rhGH was administrated on day 1 post operation and lasted for 15 days. The dynamic changes in the serum levels of IgG, IgA, IgM , T lymphocyte subgroups CD4+, CD8+ and lymphocyte count on days 3, 7, 14, 21, 28 after burn were measured. Results In rhGH treatment group, the serum levels of IgA and the CD4+and CD4+/CD8+ on the days 14, 21, 28 compared were singnificantly increased (P<0.05 or 0.01), compare with those in control group. Conclusion The clinical application of rhGH might enhance immune function in severely burned patients.
出处
《浙江医学》
CAS
2004年第11期814-815,828,共3页
Zhejiang Medical Journal
