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N-甲基-D-天冬氨酸的研究进展 被引量：5

Advance in N-methyl-D-aspartic Acid (NMDA)
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摘要 近年来研究表明 ,N 甲基 D 天冬氨酸 (NMDA)对神经和内分泌具有重要的调控作用。适量的NMDA能够显著促进动物腺垂体中生长激素 (GH)、黄体生成素 (LH)、促性腺激素释放激素 (GnRH)以及催乳素 (PRL)的分泌。本文对NMDA的结构、分布、生物合成、检测方法以及生物学功能等作一简要综述 。 Recently, studies have shown that N-methyl-D-aspartic acid (NMDA)plays an important role in regulation of the nervous tissues and endocrine glands. Many studies have shown that the excitatory amino acid N-methyl-D-aspartic acid (NMDA) is able to stimulate the release of gonadotropin releasing hormone from the hypothalamus, luteinizing hormone, prolactin, and growth hormone from the pituitary gland. The structure, distribution, determination, physiological functions of NMDA and its biosynthesis, as well as its application in the animal science are reviewed in the article.
作者 李奎 冯杰 许梓荣
机构地区 浙江大学饲料研究所
出处 《中国畜牧杂志》 CAS 北大核心 2004年第11期39-41,共3页 Chinese Journal of Animal Science
基金 国家自然科学基金资助 (编号 :3 0 0 0 0 12 0 )
关键词 畜牧、兽医科学基础学科 N-甲基-D-天冬氨酸 综述 生理活性 Basal disciplines of animal and veterinary science N-methyl-D-aspartic acid(NMDA) A review Physiological functions
分类号 S816703 [农业科学—饲料科学]
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参考文献11

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共引文献1

同被引文献46

  • 1肖英平,洪奇华,刘秀婷,刘锐钢,赵许可,陈安国,杨彩梅.谷氨酰胺对断奶仔猪生长性能、营养物质表观消化率、空肠碱性磷酸酶活性及与肠道健康相关因子基因表达的影响[J].动物营养学报,2012,24(8):1438-1446. 被引量：39
  • 2Kimihiko S, Atsuko T. Occurrence of N-methyl-L-aspartate in bivalves and its distribution compared with of N-methyl-D- aspartate and D, L-aspartate [J].Compar Biochem Physics Part B, 2001, 130:493-500.
  • 3Antimo D A, Antonella D S, Patrizia S, etal. A specific enzy matic high-performance liquid chromatography method to de termine N-methyl-D-aspartic acid in biological tissues [J]. Anal Biochem, 2002, 308:42-51.
  • 4Aniello A, Tolino G, Fisher, etal. The role of D-aspartic acid and N-methyl-D-aspartie acid in the regulation of prolactin release [J]. Endocrinology, 2000,141 : 3862-3870.
  • 5Estienne M J, Harter J M, Barb C R, et al. N-Methyl-D,L- aspratate induced growth hormone decretion in harrows: possible mechanissm of action [J]. J Anita Sci, 1996, 74: 597-602.
  • 6Gay V L, Plant T M. N-methyl-D,L-aspartate elicits hypothalamic gonadotropin-releasing hormone release in prepubertal male rhesus monkeys (Macaea mulatta) [J]. Endocrinology,1987, 120:2289-2296.
  • 7Abbud R, Smith M S. Altered luteinizing hormone and prolaction responses to excitatory amino acids [J]. Neuroendocrinology, 1993, 58 (4)456- 464.
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  • 10Hlavacek J, Poduska K, Sorm F, et al. N-methylanalogues of some peptide juvenoids [J]. Collect Czeeh Chem Commun, 1967, 41.2079 -2087.

引证文献5

二级引证文献4

中国畜牧杂志
2004年 第11期

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