鼻咽低分化鳞癌DNA分析对肿瘤治疗的意义

CLINICAL SIGNIFICANCE OF DNA ANALYSIS IN PATINENTS WITH LOW DIFFERENTIAL SQUAMOUS CELL CARCINOMA

目的:为了提高鼻咽低分化鳞癌治疗5年生存率及生活质量。方法:应用真彩色图像分析,对32例鼻咽低分化鳞癌进行DNA分析,其中1年内复发20例,5年内未复发12例。结果:两组肿瘤细胞DNA指数和DNA倍体分布,经统计学处理,具有显著差异。结论:DNA指数及DNA倍体越大,肿瘤恶性程度越高,越容易复发和转移,故应根据肿瘤细胞不同异倍体,采取不同治疗方案,才能达到较好的治疗效果。

Objective: To improve the 5 - year survival rate and quality of life of the patients of low differential squamous cell carcinoma. Method: Using the true Color Medical Image Analysis System, DNA index and DNA-ploidy were analysed in 32 cases of patients with low differential nasopharyngeal squamous cell carcinoma.Patients were divided into two groups: the relapsing group (n=20), in which the tumor relapsed within a year, and the non-relapsing group (n= 12), in which the tumor didn' t relapse within 5 years after radiotherapy, Results: The DNA indexes and DNA - ploidies were greatly different between two groups and the tumors with high DNA index and DNA- ploidy had a higher malignance than that with low DNA index and DNA - ploidy, and were likely to relapse and transfer. Conclusion: The advanced treatment according to DNA index and DNA ploidy is helpful to increase the 5-year survival rate.