摘要
力学环境在维持骨组织正常形态和功能活动中发挥着重要的影响 ,目前研究采用的细胞生物力学装置模拟了压应力、张应力及流体剪切力等不同应力模式对培养中细胞的作用。并发现成骨细胞对不同类型的力学刺激有不同的感受和应答机制 ,甲状旁腺素、应力的频率、大小等也影响着力学刺激对成骨细胞的作用效应。
出处
《北京生物医学工程》
2004年第2期158-160,共3页
Beijing Biomedical Engineering
参考文献22
-
1Carvalho RS, Bumann A, Schaffer JL, et al. Predominant integrin ligands expressed by osteoblasts show preferential regulation in response to both cell adhesion and mechanical pertubation. J Cell Biochem, 2002,84: 497 - 508
-
2Duncan RL, Chen N, Brubaker KD, et al. Mechanotransduction in bone: the role of calcium channels and intracellular calcium release in the response of osteoblasts to mechanical stimulation. [ DB/OL] www.dsls. usra. edu/dsls/meetings/ bio 2001 2002. 11
-
3You J, Yellowley CE, Donahue HJ, et al. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Engin,2000, 122:387-393
-
4Piekarski K, Munro M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature, 1977, 269: 80-82
-
5Thomas D. Brown. Techniques for mechanical stimulation of cells in vitro: a review. J Biomech, 2000, 33: 3 - 14
-
6Dong Hee Lee, Jong-Chul Park, Hwal Sub. Effect of centrifugal force cellular activity of osteoblastic MC3T-E1 cell in vitro. Yonsei Medical Journal, 2001, 42:405-410
-
7Katsuya sato, Taiji Adachi, Yoshihiro Tomita. Directional dependency of Ca2+ signaling response to meehnical stimulus in osteoblastic cell.Bioengineering conference (ASME BED), 2001, 50: 153-154
-
8Ajubi, Klein-Nulend NE, Alblas J, et al. Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes.Am J Physiol (Endocrine), 1999, 276:El71
-
9Tseng H, Berk BC. Fluid shear stress simulates mitogen-activated protein kinase in boveine aortic endothelial cells. Circulation, 1993, 88:1-84
-
10Ziros PG, Andrea-Paola Rojas Gil, Tassos Georgakopoulos, et al. The bone-specific transcriptional regulator Cbfal is a target of mechanical signals in osteoblastic cells. J Bio Chem, 2002, 277 (26): 23934-23941
同被引文献15
-
1陈光兴,杨柳,唐康来,段小军,李忠,周红星,顾祖超,林炎水.成骨诱导的兔骨髓基质干细胞成骨活性的表达及维持[J].中华创伤骨科杂志,2004,6(7):735-739. 被引量：6
-
2沈力行,丁皓,莫国民,徐根林,杜妍辰,郦鸣阳.内皮细胞应力测试装置[J].医用生物力学,2003,18(4):229-233. 被引量：2
-
3姜伟元,李惜惜,覃开荣.平行平板流动腔的合理设计和使用[J].医用生物力学,1996,11(2):97-102. 被引量：16
-
4王速,赵捷,吉田洋二,陈铁镇.流体力学模型各区域内皮细胞的形态学变化[J].中国医科大学学报,1996,25(6):551-555. 被引量：2
-
5Minguell JJ,Erices A.Mesenchymal stem cells and the treatment of cardiac disease[J].Exp Biol Med (Maywood),2006,231(1):39.
-
6Arinzeh TL,Mesenchymal.stem cells for bone repair:preclinical studies and potential orthopedic applications[J].Foot Ankle Clin,2005,10(4):651.
-
7Yamamoto K,Sokabe T,Watabe T,et al.Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro[J].Am J Physiol Heart Circ Physiol,2005,288(4):H1915.
-
8Sho E,Komatsu M,Sho M,et al.High flow drives vascular endothelial cell proliferation during flow-induced arterial remodeling associated with the expression of vascular endothelial growth factor[J].Exp Mol Pathol,2003,75(1):1.
-
9Huang H,Nakayama Y,Qin K,et al.Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading[J].J Artif Organs,2005,8(2):110.
-
10Steck R,Niederer P,Knothe Tate ML.A finite element analysis for the prediction of load-induced fluid flow and mechanochemical transduction in bone[J].J Theor Biol,2003,220(2):249.
-
1郭来威,许田恩,孟会强,滕元君,夏亚一.机械应力对成骨细胞影响的研究进展[J].中国医学物理学杂志,2015,32(6):785-789. 被引量：5
-
2徐勇,蒋青.关节软骨细胞生物力学研究进展[J].江苏医药,2009,35(8):954-955. 被引量：4
-
3曾衍钧.生物力学现状与展望[J].北京工业大学学报,1996,22(1):3-4. 被引量：1
-
4赵志河,李宇.正畸牙移动细胞生物力学研究进展[J].医用生物力学,2010,25(6):393-398. 被引量：15
-
5凯瑟琳·阿恩斯坦,吴学华.现成的人体器官[J].商业周刊（中文版）,2003(9):54-55.
-
6廖福龙.读《细胞生物力学与临床应用》[J].生物医学工程学杂志,2012,29(5):1014-1014.
-
7郑诚功.组织工程与细胞生物力学的进展[J].中华创伤骨科杂志,2006,8(10):901-902. 被引量：4
-
8李雪萍,钱雪琴,钱利生.志贺菌对HeLa细胞侵袭力的研究[J].中国生物工程杂志,2005,25(6):71-75. 被引量：2
-
9阮光萍,姚翔,刘菊芬,王金祥,何洁,杨建勇,潘兴华.树鼩血清与多种二抗的交叉反应:可在树鼩疾病动物模型中广泛应用[J].中国组织工程研究,2015,19(5):794-798. 被引量：1
-
10赵彬,要航,吴燕,汪家政,王福庄,范明.PCR标记探针原位检测培养的海马神经细胞BDNF mRNA的表达[J].神经解剖学杂志,1997,13(3):221-224. 被引量：1
