家禽垂体特异转录因子POU1F1研究进展

Progress on Pituitary-specific Transcription Factor (POU1F1) in Poultry

催乳素 (Prolactin ,PRL)、生长激素 (GrowthHormone ,GH)、促甲状腺素 β(Thyroid stimulatingHormone β ,TSHβ)是家禽垂体前叶分泌的具有重要生理功能的激素 ,这些激素通过调控家禽就巢性的发生与维持、生长发育、免疫应答等过程来影响家禽的产蛋性能、生长性能以及免疫力。垂体特异转录因子POU1F1(Pituitary specificTranscriptionFactor)是家禽垂体前叶特异表达的一种具有重要功能的转录因子 ,它与PRL基因、GH基因、TSHβ基因以及Pit 1自身的启动子结合 ,调控这些基因的转录 ,通过调节这些基因的表达而对家禽的生长发育、繁殖等很多方面起着重要的作用。比较了家禽Pit 1基因的结构与哺乳动物的差异 ,阐述了家禽Pit 1基因的表达特点及其生物学效应。考虑到POU1F1的重要作用和作者的研究 ,作者认为Pit 1基因可作为家禽生长、产蛋。

Prolactin (PRL),Growth Hormone (GH), and Thyroid-stimulating Hormone-β(TSHβ), secreting by chicken anterior pituitary, are essential hormones affecting chicken laying ability, growth rate, and immunity via regulating chicken broodiness, development, and immune response. Avian pituitary-specific transcription factor (POU1F1) is one of important transcription factors of GH, PRL, and TSH β gene. POU1F1 plays an important role in avian growth, development and reproduction via regulating the expression of these genes. The gene organization and the expression characters of poultry Pit-1 were discussed comparing with those of mammals, and the functions of POU1F1 were also elucidated in the review. Considering the biological importance of POU1F1 and the results got in our research, we suggested that Pit-1 be a candidate gene for growth, egg laying and broodiness research in poultry.