复合同源异型结构的研究进展

The Progress in Complex Homeobox Domains

含有同源异型结构 (homeobox)的蛋白质是一大类DNA结合蛋白 ,在胚胎发育、基因表达调节、细胞分化、神经发生等方面发挥重要作用。近年来发现了同源异型框与其他结构域同时存在 ,如PAX、POU、LIM、OAR、CUT、ELK、bZIP、SIX、PHD finger、Engrailed等 ,近来还发现它通过基因融合或基因失调控方式参与肿瘤的发生。本文对这些含有复合同源框的蛋白质和基因的类型、结构。

The proteins with ’homeobox’ (HOX) domain, a large family of DNA binding, play an important role in embryonic development, gene regulation, cell differentiation and neurogenesis. Some other domains are found in the proteins together with HOX, such as PAX, POU, LIM, OAR, ELK, SIX, bZIP, PHD-finger, Engrailed, hexapeptide domains. The HOX combined with other domains that associate with DNA binding or protein interactions are called “complex homeobox”. Recent reports indicate that “complex homeobox” genes also take part in tumorigenesis by the way of gene fusions and deregulation. The progress of “complex homeobox” in types, structures and functions have been summarized in this review.