银杏酮酯对实验性心肌缺血和血液流变性的影响

Effects of Extracts of Ginkgo Leaves on the Experiment Myocardial Ischemia and Blood Hemorheology

目的观察银杏酮酯(EGB)对急性心肌梗死、急性心肌缺血和血液流变性的影响。方法结扎左冠状动脉前降支,观察EGB对犬急性心肌梗死的影响;静脉注射脑垂体后叶素,观察EGB对大鼠急性心肌缺血的影响;家兔静脉注射给药,观察EGB对血液流变性的影响。结果EGB可明显减小犬心肌梗死范围,明显降低心肌梗死后乳酸脱氢酶和磷酸肌酸激酶活性,抑制垂体后叶素所致的大鼠心肌缺血心电图ST段升高。可不同程度地降低家兔全血粘度及血浆粘度。结论EGB能显著地保护缺血损伤心肌,其机制可能与缩小急性心肌梗死范围及减轻梗死程度、缓解急性心肌缺血、明显改善血液流变性指标有关。

Objective To observe the effects of extracts of ginkgo leaves (EGL) on acute myocardial infarction, acute myocardial ischemia and blood hemorheology.Methods The effects of EGL on acute myocardial infarction were observed in dogs model induced by the ligation of anterior descending branch of left coronary artery; effects on acute myocardial ischemia were observed on rats model caused by intravenous injection of pituitrin and effects on blood hemorheology were observed in rabbits. Results EGL significantly reduced the myocardial infarction area, decreased the activities of lactate dehydrogenase and creatine phosphokinase in dogs, reduced the elevation of ST segment of electrocardiogram in rats with myocardial ischemia and decreased whole blood viscosity and plasma viscosity in rabbits. Conclusion EGL has protective effect against myocardial ischemic injury and can improve the parameters of blood hemorheology in rabbits. Its mechanism may be concerned with the reduction of the myocardial infarction area and infarction degree and the relief of acute myocardial ischemia.