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NMD作用的顺式调控元件 被引量：1

Progress on Cis-acting Regulatory Elements in Nonsense-mediated mRNA Decay
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摘要 真核生物利用无义介导的mRNA降解 (nonsense mediatedmRNAdecay ,NMD) ,对含有提前终止密码子(prematureterminationcodons ,PTC)的异常转录产物进行快速清除 ,防止毒害性截短蛋白 (truncatedproteins)的产生 ,是真核生物重要的mRNA监视机制。NMD作用的启动与多种顺式调控元件有关 ,它们包括 :提前终止密码子的标识 ;PTC下游特定位置的序列元件 ,在酵母细胞称为DSE (downstreamsequenceelement,DSE) ,在哺乳动物细胞主要为内含子剪接依赖性序列元件 (exon exonjunction ,EEJ) ;稳定作用元件 (stabilizerelements ,STE)对NMD作用的阻抑调节 ;以及其他与NMD作用相关的序列 ,如 poly(A)延长、5′ UTR的uORF(upstreamopenreadingframe ,uORF)和程序化核糖体移码 (programmed 1ribosomalframeshift, 1PRF)信号序列等。 In eukaryotic cells,nonsense-mediated mRNA decay (NMD) is an effcetive mRNA surveillance mechanism that detects and degrades mRNAs with premature termination codons (PTC) and protects cells from the potentially deleterious effects of truncated proteins.Some cis-acting regulatory elements have been reported involving in NMD.They are PTC presence,PTC recongnation by downstream elements that termed as downstream sequence element (DSE) in yeast and primarily exon-exon junction (EEJ) in mammalian cells,stabilizer sequence (STE) inactivation the NMD,and other sequences correlated with NMD such as extended poly (A) in 3′ UTRs,upstream open reading frame (uORF) located in 5′ UTR and programmed -1 ribosomal frameshift (-1 PRF).Progress on cis-acting regulatory elements in nonsense-mediated mRNA decay was reviewed in this paper.
作者 黄峙 周天鸿 郭宝江
机构地区 暨南大学生命科学技术学院 华南师范大学生命科学学院 华南师范大学生命科学学院
出处 《Acta Genetica Sinica》 SCIE CAS CSCD 北大核心 2004年第11期1321-1326,共6页
基金 国家自然科学基金项目 (编号 :3 0 3 70 776)资助~~
关键词 无义介导的mRNA降解 NMD 顺式调控元件 提前终止密码子(PTC) 截短蛋白 nonsense-mediated mRNA decay (NMD) cis-acting regulatory elements premature termination codons (PTC) truncated proteins
分类号 Q522 [生物学—生物化学]
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参考文献42

  • 1Hosoda N,Kobayashi T,Uchida N,Funakoshi Y,Kikuchi Y,Hoshino S,Katada T.Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.J Biol Chem,2003,278(40): 38287-38291.
  • 2Jacobson A,Peltz S W.Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells.Annu Rev Biochem,1996,65: 693-739.
  • 3Maquat L E,Carmichael G G.Quality Control of mRNA Function.Cell,2001,104(2): 173-180.
  • 4Couttet P,Grange T.Premature termination codons enhance mRNA decapping in human cells.Nucleic Acids Res,2004,32 (2): 488-494.
  • 5Dahlseid J N,Lew-Smith J,Lelivelt M J,Enomoto S,Ford A,Desruisseaux M,McClellan M,Lue N,Culbertson M R,Berman J.mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae.Eukaryot Cell,2003,2(1): 134～142.
  • 6Ionov Y,Nowak N,Perucho M,Markowitz S,Cowell J K.Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.Oncogene,2004,23(3): 639-645.
  • 7Palacios I M,Gatfield D,St Johnston D,Izaurralde E.An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.Nature,2004,427(6976): 753-757.
  • 8Losson R,Lacroute F.Interference of nonsense mutations with eukaryotic messenger RNA stability.Proc Natl Acad Sci USA,1979,76(10): 5134-5137.
  • 9Daar I O,Maquat L E.Premature translation termination mediates triosephosphate isomerase mRNA degradation.Mol Cell Biol,1988,8(2): 802-813.
  • 10Urlaub G,Mitchell P J,Ciudad C J,Chasin LA.Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.Mol Cell Biol,1989,9(7): 2868-2880.

同被引文献24

  • 1Wall R J. Transgenic livestock: progress and prospects for the future [ J ]. Theriogenology, 1996, 45 : 57 -68.
  • 2Goldman I L, Kadulin S G, Razin S V. Transgenic gnats in the world pharmaceutical industry of the 21st century [ J]. Russian Journal of Genetics, 2002, 38(1): 1-14.
  • 3Maga E A, Murray J D. Mammary gland expression of transgenes and the potential for altering the properties of milk [J]. Bio/Technol, 1995, 13:1452-1457.
  • 4Bleck G T, Jimenez-Flores R, Bremel R D. Abnormal properties of milk from transgenic mice expressing bovine B-casein under control of the bovine α-lactalbumin 5' flanking region [J]. Int Dairy J, 1995, 5:619 -632.
  • 5Houdebine L M. Transgenic animal bioreactors [ J]. Transgenic Res, 2000, 9:305 -320.
  • 6Dale T C, Kmacik M J, Schmidhauser C. et al. High level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 30 untranslated region [J]. Mol Cell Biol, 1992, 12:905-914.
  • 7Bonifer C. Long-distance chromatin mechanisms controlling tissue-specific gene locus activation [J]. Gene, 1999, 238:277 -289.
  • 8Giraldo P, Montoliu L. Size matters: use of YACs, BACs and PACs in transgenic animals [J]. Transgenic Res, 2001, 10:83 -103.
  • 9Forrester W C, Fernandez L A, Grossehedl R. Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions [J]. Gene Dev, 1999, 13:3003-3014.
  • 10Fedosyuk H, Peterson K R. Deletion of the human 13-globin LCR 5'HS4 or 5'HS1 differentially affects β-like globin gene expression in β- YAC transgenic mice [J]. Blood Cells Mol Dis, 2007, 10:1016.

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Acta Genetica Sinica
2004年 第11期

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