围手术期患者应用抗感染药物的调查分析

Antibiotics Usage in Patients During Perioperative Period: Investigation and Analysis of the Situation

目的 分析我院围手术期抗感染药物的应用及合理性。方法 随机抽取我院 2 0 0 1年围手术期病例 16 3份 ,从抗感染药物的种类、用药频度、联合用药、预防用药的时间和数量、术后用药天数及术后感染等进行调查分析。结果 预防性使用抗感染药物病例共 15 1例 ,联合用药占 79.75 % ;应用 1种或 2种药物与应用 >3种药物之间的感染率差异有显著意义 (P <0 .0 5 ) ;术前 0 .5～ 1h或术中给药与术后当日给药患者之间的感染率差异有显著性意义 (P <0 .0 5 ) ;术后用药时间 1～ 4d与 >5d的患者感染率差异有显著性意义 (P <0 .0 5 ) ;抗感染药物共涉及 7类 2 5种。结论 应加强围手术期抗感染药物使用的管理和监督 ,强化临床医生合理用药。

OBJECTIVE To analyze the situation of antibiotics usage in patients during perioperative period. METHODS The antibiotics used in 163 patients during perioperative period in 2001, were investigated and analyzed in respect of kinds, frequency, use in combination, the situation of administration for prophylaxis such as time, amount and duration after operation, and the situation of infection after operation, et al. RESULTS There were 151 cases used for prophylaxis, of which, combination administration accounted for 79.75%. There were significant differences between the application of one or two drugs and of three drugs (P<0.05) between administration 0.5-1 hour before or during the operation and after operation (P<0.05), and between administration after operation continued for 1-4 days and continued for more than 5 days (P<0.05). CONCLUSIONS The supervision and management towards the perioperative application of antibiotics should be strengthened and the reasonable advice for medicine usage should be given to clinical physicians.