NO偶联双氯芬酸衍生物抗炎、镇痛、解热作用实验研究

An Experimental Study on the Anti-inflammatory, Analgesic and Antipyretic Activities of a NO-coupled Diclofenac Derivative

目的 :考察NO偶联双氯芬酸衍生物 (澳通 ,CO 3)的抗炎、镇痛、解热作用。方法 :通过小鼠耳二甲苯致炎、角叉菜胶致大鼠足跖肿胀、大鼠棉球肉芽肿及Ⅱ型胶原所致的大鼠关节炎等实验模型 ,观察CO 3的抗炎作用 ;通过小鼠醋酸扭体、热板刺激和大鼠甩尾等实验模型 ,观察CO 3的镇痛作用 ;通过大鼠啤酒酵母致热实验模型 ,观察CO 3的解热作用。结果 :CO 3可明显抑制二甲苯所致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀、大鼠棉球肉芽组织增生及Ⅱ型胶原所致的大鼠关节炎 ;能显著抑制醋酸引起的小鼠扭体反应及提高甩尾及热板刺激的致痛阈值 ;对啤酒酵母致热大鼠有明显的解热作用。结论 :CO 3具有良好的抗炎、镇痛、解热作用。

Objective:To investigate a nt i-inflammatory, analgesic and antipyretic effects of CO-3, a NO-coupled diclo fenac derivative, in laboratory animal s. Methods: The anti-inflammatory activities were tested using various inflammatory models including ear swelling induced by xylene in mice, ra t paw edema induced by carrageenin, cotton pellet granuloma and arthritis induce d by Ⅱ collagerr in rats; the analgesic activities were tested using pain model s caused by hot board and acetic acid in mice and tail-stimulation models in rats ;The antipyretic activity was tested using fever models induced by beer yeast in rats. Results: CO-3 inhibited ear-swelling induced by xylen e, rat paw edema induced by carrageenin, cotton pellet granuloma and arthritis i nduced by Ⅱ collagerr significantly;inhibited obviously twisting induced by ac etic acid and prolonged the pain threshold in tail-stimulation and hot board te st and markedly inhibited fever induced by beer yeast. Conclusion:CO-3 has anti-inflammatory,analgesic and antipyretic activities. [