子宫上皮样滋养细胞肿瘤的临床病理特征

Clinicopathologic characteristics of uterine epithelioid trophoblast tumor

目的 探讨子宫上皮样滋养细胞肿瘤 (ETT)的临床病理特征。方法 分析 1例合并局灶绒毛膜细胞癌的临床和病理资料 ,结合文献进行讨论。观察病变的大体及镜下特点 ,采用HE染色及免疫组化S P法测定CK(AE1/AE3)、HPL、HCG、α inhibin。结果 肿瘤由绒毛膜型中间滋养细胞组成 ,瘤细胞巢呈地图样分布 ,瘤巢间充满嗜酸性透明变性物质。肿瘤的免疫表型 :CK(AE1/AE3)、HPL、PLAP和α inhibin均呈阳性表达。结论 ETT为滋养细胞肿瘤的新类型 ,系由绒毛膜型中间滋养细胞组成 ,属于低度恶性肿瘤。ETT应与胎盘部位滋养细胞肿瘤、胎盘部位结节、绒毛膜细胞癌和宫颈鳞癌鉴别。

Purpose To explore the clinicopathologic characteristics of uterine epithelioid trophoblast tumor(ETT). Methods The clinicopathological data of 1 case of ETT coexsisting with focal choriocarcinoma was analysed and discussed in reference of the literature. The lesions were observed grossly and microscopically. The HE staining and detection for CK(AE1/AE3)、HPL、HCG、α-inhibin with S-P method were performed. Results The tumors were composed of chorionic type intermediate trophoblast cells, which distributed in a geographical pattern with eosinophilic hyalinized degenerative materials among nests. CK(AE1/AE3), HPL, HCG and α-inhibin positively were expressed in tumor cells. Conclusions ETT is identified as a new type of trophoblast tumor. It consists of the chorionic type intermediate trophoblast cells, and belongs to low grade malignancy. ETT should be differentiated with placenta site trophoblast tumor, placenta site nodule, choriocarcinoma, and cervical squamous cell carcinoma.