胶质瘤TGF-β1、p53、PTEN表达及其临床意义

Expression of TGF-β1, p53 and PTEN in human gliomas and its clinical significance

目的 探讨 TGF- β1、p5 3、PTEN蛋白在不同恶性程度胶质瘤中的表达及临床意义。方法 应用免疫组化 Eli Vision TM二步法检测 92例胶质瘤中 TGF- β1、p5 3、PTEN蛋白的表达。结果 TGF- β1、p5 3与胶质瘤级别呈正相关 ,高分化组与低分化组组间差异有显著性 (P<0 .0 5、P<0 .0 1) ;PTEN与胶质瘤级别呈负相关 ,高分化组与低分化组组间差异有显著性 (P<0 .0 5 ) ;TGF- β1与 p5 3的表达呈正相关 (r=0 .2 31、P<0 .0 5 ) ;PTEN不表达、p5 3表达的胶质瘤患者预后差 (P<0 .0 5、P<0 .0 5 )。结论 PTEN、p5 3的表达与预后密切相关 。

Objective To investigate the expression o f TGF-β1, p53 and PTEN in human gliomas and their correlation with prognosis o f gliomas. Methods The expressions of TGF-β 1, p53 and PTEN i n 92 specimens of human glioma were detected with immunohistochemical staining b y EliVision TM. Results The expression of TGF-β1 and p53 had positive correlation with progression of pathological grade(P<0.05 and P<0.01,respectively). The expression of PTEN had negative correlation with progression of pathological grade(P<0.05). The expression of TGF-β1 was p ositively correlated with that of p53 (P<0.05).The negative expressions of P TEN and postive expitstion of p53 were correlated with poorer prognosis of patie nts(P<0.05, P<0.05).Conclusion The detection of PTEN and p5 3 expression in glioma might be valuable in evaluation of tumor malignancy and p rognosis of patients.