硬膜外小剂量布比卡因与芬太尼/氯胺酮对分娩镇痛的临床研究

Clinical Study on Extradural Analgesia with LOW-dose Bupivacaine Adding Fentanyl/or ketamine in Labour

本文以小剂量布比卡因与芬太尼/氯胺酮硬膜外阻滞对分娩镇痛的研究104例,结果:0.15％布比卡因含芬太尼50μg镇痛满意,对母体、胎儿/新生儿无不良影响,安全可靠,适于推广应用;0.15％布比卡因含氯胺酮30mg和0.25％布比卡因均有一定的不良反应,对分娩镇痛不太理想。

One hundread and four healthy primiparae at term with uncomplicated pregnancies or labours receiving ex-tradural analgesia who dilivered normolly were studied. The parturients were divided randomly into four groups. The contral group (group A)hadn’t received any sedatives and analgesics. The treated groups (containing group B,C and D)were administered extradurally randomly with different concentration bupivacaine and fentanyl or ketamine. Group B with 0.15％ bupivacaine added fentanyl 50μg,group C with 0.15％ bupivacaine added ketamine 30mg ,and group D with 0.25% bupivacaine alone. All the first total doses were 8ml (3ml plus 5ml). The results showed group B expressed satisfactory analgesia and maternity, fetus or newborn encountered no obvious sideeffects. It is concluded that 0.15％ bupivacaine and fentanyl 50μg extradural administrations are even safer,effective and suit-able for lobour.