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T淋巴细胞性白血病病人CCR9的功能改变

The changes of functions of chemokine receptor 9 on T cell lymphocytic leukemia patients
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摘要 目的 :探讨趋化性细胞因子受体 9(CCR9)在白血病病人中的功能改变。方法 :对 38例T淋巴细胞性白血病病人的血液标本进行分析。采用趋化试验和黏附试验检测胸腺表达的趋化性细胞因子TECK CCL2 5 (CCR9的配体 )对病人CD4+T细胞的趋化功能和黏附功能的改变。结果 :TECK CCL2 5可以诱导几乎所有的急性T淋巴细胞性白血病 (T ALL)患者的CD4 +T细胞产生强趋化移动 ,也可介导其发生较强的黏附作用 ,而对慢性T淋巴细胞性白血病 (T CLL)患者的CD4 +T细胞仅显示出中度的趋化和黏附作用。结论 :CCR9及其配体TECK可能与促进T ALLCD4 +T细胞的迁移和浸润有关。 Objective:To observe the influences of functions of chemokine receptor 9(CCR9) on leukemia patients,we analyzed 38 typical T cell lymphocytic leukemia cases.Methods:The functions of T ALL and T CLL CD4+T cells towards TECK/CCL25 were determined by chemotaxis assay and adhesion assay.Results:Almost in all of the T ALL patients,TECK/CCL25(a ligand for CCR9)could induce a high chemotactic migration of T ALL CD4+ cells as well as a high adhesion.Conclusion:It indicates that CCR9 and its ligands may promote survival or proliferation of T ALL cells. [
作者 胡志芳 张秋萍 陈会敏 董兴高 谢珞琨 何玉玲
机构地区 武汉大学医学院免疫系
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2004年第12期825-827,共3页 Chinese Journal of Immunology
关键词 趋化性细胞因子受体9 TECK 急性T淋巴细胞性白血病 慢性T淋巴细胞性白血病 CCR9 TECK T ALL T CLL
分类号 R733.71 [医药卫生—肿瘤]
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参考文献9

  • 1Yoshie O,Fujisawa R,Nakayama T et al.Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type I-transformed T cells [J].Blood,2002;99:1505-1511.
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中国免疫学杂志
2004年 第12期

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