顽固性咽部溃疡中T淋巴细胞亚群的分布

T lymphocyte subsets distribution in recurrent pharyngeal ulcer

目的 :检测顽固性咽部溃疡 (recurrentpharyngealulcer,RPU)中T淋巴细胞亚群的分布 ,探讨T淋巴细胞介导的免疫反应在咽部溃疡复发中所起的作用。方法 :应用免疫组织化学SP技术检测RPU组 36例和正常对照组 6例咽部黏膜组织中浸润细胞CD4 +、CD8+ 、HLA DR+ 的表达 ,并进行统计学分析。结果 :RPU组咽部组织黏膜中CD4 + 细胞较对照组明显减少 ,CD8+ 细胞较对照组明显增多 ,CD4 + CD8+ 比值明显下降 (P <0 0 5 ) ;巨噬细胞、T淋巴细胞高表达HLA DR抗原 (P <0 0 5 )。结论 :顽固性咽部溃疡中有大量T淋巴细胞分布 ,且T细胞亚群比例失调 ,显示细胞免疫功能的紊乱在咽部溃疡的形成与复发中起重要作用。

Objective:To observe the T lymphocyte subsets distribution in recurrent pharyngeal ulcer (RPU).Methods:Pharyngeal mucosa from 6 normal individuals and 36 patients of recurrent pharyngeal ulcer were studied with immunohistochemistry SP technique to examine the expression of CD4 +、CD8 +、HLA DR +.The results were stastically analized.Results:CD4 +T lymphocyte in RPU decreased than the control group,CD8 +T lymphocyte in RPU increased than the control group,the proportion of CD4 +/CD8 + declined obviously.HLA DR Ag was strongly expressed on activated T cells,macrophages.Conclusion:There is a great deal of T lymphocyte infiltration in RPU.The chang of T lymphocyte subsets indicates that cell immunoreaction play an important role in RPU. [