伊氏锥虫与小鼠细胞的粘附反应研究

ADHESION OF TRYPANOSOMA EVANSI TO MOUSE CELLS

本文探讨了伊氏锥虫在体外与小鼠淋巴细胞、巨噬细胞和上皮细胞间的粘附反应。结果表明，三种健康细胞与锥虫有不同程度的粘附性，不同个体来源的细胞的粘附反应存在差异，但是，各类细胞的粘附率之比基本稳定。动物受到感染后，粘附细胞数大幅度减少。人α－干扰素可以促进健康细胞以及受感染动物细胞与锥虫的粘附性。细胞粘附水平高的个体在疾病的后期表现有较强的耐受力。作者认为，小鼠多种细胞表面存在着伊氏锥虫的病原性受体，后者与动物的抗锥虫感染能力以及疾病发生都有明显相关性。

The adhesiveness of Trypanosoma evansi to mouse cells was investigated.Different adhesion capacity existed among lymphocytes. macrophages and epithelial cells. bat the adhesion ratio between them was constant. The capacity of different individuals was heterogeneous.When the animals were infected with T. evansi. their adhesive cell number was significantly decreased. Human α-interferon could promote the cell reactivity to trypanosomes of both healthy and infected mice. Interestingly, individuals with higher cell adhesion capacity could survive longer since trypanosomemia started. It was suggested that receptors to trypenosomes present on the surface of kinds of mouse cells, which closely related with the disease development.