参麦注射液救治过敏性休克的临床研究

Treatment of 60 anaphylactic shock patients with Shenmai injection

目的 观察参麦注射液救治过敏性休克患者微循环、血压、尿量的影响。方法 在现代医学常规治疗过敏性休克的基础上辅以静推参麦注射液治疗过敏性休克患者 60例 (治疗组 ) ,观察治疗前后血液流变学变化、意识状态、生命体征、血压、尿量及无创血氧饱和度 ,并与常规治疗过敏性休克患者 3 6例 (对照组 )进行比较。结果 治疗后 4h血压回升率治疗组 68.3 %,对照组 2 2 .2 %;治疗后 6h血压回升率治疗组 93 .3 %,对照组 44 .4%(P <0 .0 1) ;治疗组治疗后 2、3、4、5、6h尿量平均值明显高于对照组 (P值除治疗后 5h <0 .0 5外 ,其余均 <0 .0 1) ;治疗组治疗后血液流变学指标较对照组明显改善 (P <0 .0 1)。结论 在现代医学常规治疗过敏性休克的基础上辅以静推参麦注射液 。

Objective To assess the clinical efficacy of Shenmai injection for the treatment of anaphylactic shock patients and to observe the changes of microcirculation, blood pressure, and volume of urine. Methods Sixty cases of anaphylactic shock were treated with Shenmai injection plus Western medicine (treatment group) and 36 cases of anaphylactic shock treated with Western medicine only(control group). Hemorheological changes, consciousness, temperature, pulse and NSPO 2 were compared. Results The blood pressure recoverable rate of anaphylactic shock in the treatment group was significantly higher than that in the control group. The blood pressure recoverable rates at 4 h after the therapy were 68.3% and 22.2% in the treatment group and the control group, respectively. The average urine volume of treatment group at 2, 3, 4, 5 and 6 h after the therapy was significantly higher than that of the control group ( P <0.05 at 5 h and P <0.01 at 2, 3, 4 and 6 h). Microcirculation in the treatment group was improved obviously compared with that of the control group ( P <0.01). Conclusion Shenmai injection plus Western medicine is much better than Western medicine alone for the treatment of anaphylactic shock patients.