3Ikawa S,Fukui M,Ueyama Y,et al.B-raf,a new memberof the raf family is activated by DNA rearrangement[J].Mol Cell Biol,1988,8(6):2651-2654.
4Davies H,Bignell GR,Cox C,et al.Mutations of the BRAF gene in human cancer[J].Nature,2002,417:949-954.
5Mitsutake N,Knauf JA,Mitsutake S,et al.ConditionalBRAFV600E expression induces DNA synthesis,apoptosis,dedifferentiation,and chromosomal instability in thyroid PCCL3 cells[J].Cancer Res,2005,65(6):2465-2473.
6Knauf JA,Ma X,Smith EP,et al.Targeted expression ofBRAFV600E in thyroid cells of transgenic mice results inpapillary thyroid cancers that undergo dedifferentiation[J].Cancer Res,2005,65(10):4238-4245.
7Yuen ST,davies H,Chan TL,et al.Similarity of the phenotypicpatterns associated with BRAF and KRAS mutations in colorectal neoclassic[J].Cancer Res,2004,62(22):6451-6455.
8Houben R,Becker JC,Kappel a,et al.Constitutive activation ofthe Ras-Raf signaling pathway inmetastatic melanoma is associated with poor prognosis[J].J Carcinog,2006,3(1):6-18.
9Hynes RO.Integrins:Versatility,modulation and signaling in cell adhesion[J].Cell,1992,69(1):11-25.
10Hebbar M,Peyrat JP.Significance of soluble endothelial molecule E-selection in patients with breast cancer[J].Int J Biol Makers,2000,15(1):15-21.