喉癌表皮生长因子和c-erb B-2基因表达的免疫组化研究

Immunohistochemical study of epidermal growth factor and c-erb B-2 gene expression in human laryngeal carcinoma

对44例喉鳞癌组织分别进行了表皮生长因子(EGF)和c-erb B-2基因免疫组化研究。结果是:①EGF主要位于细胞浆内,c-erb B-2主要位于细胞膜;②EGF染色阳性为28例(63.6％),c-erb B-2染色阳性23例(52.3％);③EGF阳性率随病理学分级递增而增高;④c-erb B-2阴性病例的术后复发或死亡率为73.9％,而c-erb B-2阴性病例术后复发或死亡率为42.9％。提示,喉鳞癌细胞的分化程度与EGF表达密切相关;c-erb B-2阳性患者预后不良。

Immunohistochemical study for epidermal growth factor(EGF) and c-erbB-2 gene were performed on 44 laryngeal specimens taken out from laryngeal carcinoma patients. The results showed that EGF was localized to the cytoplasm,and c-erbB-2 was localized to the cell membrance. The positive rates of EGF and c-erbB-2 were 63. 6% (28 cases) and 52. 3% (23 cases) respectively. This study indicated that there was obvious correlation between the division degree of laryngeal carcinoma cell and expression of EGF,and that c-erbB-2 gene expression might be related to'clinical prognosis of laryngeal carcinoma patients.