11例各类肌炎的病理学表现

Pathological Manifestations of 11 Cases of Different Types of Myositis.

目的:探讨各类肌炎的病理学特点。方法:对11例患各类肌炎病人的肌肉活检标本进行常规染色、特染、组织酶学染色及超微结构病理研究。结果:11例肌炎病人中感染性肌炎3例,其病理形态表现各具特征。免疫介导性肌炎8例,其病理形态的共同点是坏死肌纤维位于肌束周边,伴灶性炎细胞浸润、小血管壁增厚。结论:苏木精-伊红染色是诊断各种肌炎的主要方法,特染和组织酶学染色对诊断肌炎有辅助作用,电镜下超微结构的观察对包涵体肌炎有诊断价值。

Objective: To investigate the pathological features of different type of myositis. Methods: Muscle-biopsied specimens from 11 patients with myositis were analysed with routine staining, special and bistochemical staining of enzymes. Ultra-structure study was made under electron microscopy. Results: Three cases were diagnosed as infective myositis which showed different pathological features according to the etiology. Eight cases were diagnosed as immune-mediated myositis in which the common pathological findings were necrotic muscle fibers around muscle bundles, accompanied by focal inflammatory invasion and swelled perivascular walls. Conclusions: Routine staining was a main tool for diagnosing myositis, special and histochemical staining might be helpful for the diagnosis, and ultra-structure observation under electron microscopy was valuable for the diagnosis of inclusion body myositis.