肺动脉灌注化疗治疗晚期肺癌31例报告

REPORT ON TREATMENT FOR 31 CASES OF ADVANCED PULMONARY CARCINOMA WITH CHEMOTHERAPEUTIC INFUSION IN PULMONARY ARTERY

目的探讨肺动脉灌注化疗治疗晚期肺癌的方法和效果。方法 31例晚期肺癌施行姑息性切除术23例,单纯探查术8例。术中附加安置全植入式导管药盒系统。灌注药物分别有:泰素(Taxol)、诺维苯(NWB)、顺铂(DDP)、长春新碱(VCR)、异环磷酰胺(Holaxin)、阿霉素(ADM)、5-FU(5-氟脲嘧啶啶)等。31例共灌注65次。一般两种药物联合应用;术后3～4周开始灌注,2～5次为一疗程。结果症状明显缓解有10例,部分缓解有16例,病情进展较快的有5例。结论作者认为肺动脉灌注化疗是对晚期肺癌综合治疗的辅助方法之一。

Objective To detect the procedure and the role in treatment for advanced pulmonary carcinoma with chemotherapeutic infusion in pulmonary artery. Methods: 25 cases were in stage Ⅲ b, 6 in stage Ⅳ, a total of 31 cases were treated by surgical procedure. Among the drugs infused were CDDP, ADM, VCR, 5-FU and TaxoI. Generally two to three of the drugs were jointly used in respective infusion. The drugs were usually given by infusion once every postoper ative three or four weeks, and two to five chemotherapeutic infusions constituted a course of treatment. Results: In this se ries the remission or partial remission of syndrome was obtained in 26(83.87%) cases, and 5 cases progressed. Conclu lions: Chemotherapeutic infusion in pulmonary artery can yet be regarded as an assistant way of treatment for pulmonary carcinoma.