子宫内膜异位症的免疫学检查与临床应用

IMMUNOLOGICAL STUDY ON ENDOMETRIOSIS AND ITS CLINICAL EVALUATION

在纯化子宫内膜抗原的基础上,建立了检测抗子宫内膜抗体、子宫内膜抗原和特异性免疫复合物的ELISA 法,发现子宫内膜异位症患者这三项指标的阳性率都有显著升高。在临床早期伴有不育的患者,抗子宫内膜抗体检出率高达90%,提示此抗体可能对妊娠有严重干扰。

On the basis of the isolation and purification of endometrium antigen,three immunological assays for thediagnosis of endometriosis,including the quantitative detections of endometrium antigen(EMAg),antiendometrium autoantibody(EMAb)and EMAg-specific immune complex(EM-IC)were established.Theresults of clinical studies showed that there were significantly higher positive rates of the three indexes in the pa-tients with endometriosis.The EMAb positive rate in such patients with infertility even reached to 90%,suggestingthat the autoantibody may severely interfere with the pregnancy process.