老年人牙周炎牙龈组织内抗原提呈细胞的免疫组织化学研究

Immunohistochemical Study of Antigen Presenting Cells in The Gingiva of Periodontitis in Old Age

利用抗T6及HLA-DR二种单克隆抗体对12例老年9例成人牙周炎患者牙龈组织内Langerhan's细胞及巨噬细胞进行免疫组化染色观察。发现Langerhan's细胞位于上皮棘细胞及基底胞层,而巨噬细胞位于结缔组织靠近上皮处。老年人与成人牙周炎之间的Langerhan's细胞和巨噬细胞数差异显著。作者认为:巨噬细胞在老年人牙周炎免疫调节中起重要作用。

Gingiva tissue from 12 cases of old periodontitis patients and 9 cases of adult periodontitis and 5 cases of old persions with healthy gingiva have been stained im-munohistochemically with a monoclonal anti T6, HLA -DR antibodies to aid in the identification and quntification of langerhan's cell and macrophage. The results showed that langerhan's cell located in the poly gonal cells layer and basal cells layer of gingiva, while macrophage located in the connective tissue. The difference of langerhan's cell and macrophage between old age periodontitis and adult periodontitis was very significant. The results suggest that macrophage play an important role in the immunol regulatory of old age periodontitis; langerhan's cell play a crucial part in that of adult periodontitis.