卡马西平、苯妥英钠的耐受性研究

Tolerance to phenytoin and carbamazeping in patients with epilepsy

本文报告在血浓度监测下对327例癫痫病人进行卡马西平、苯妥英钠耐受性研究的结果。发现:4％的癫痫病人对卡马西平有先天耐受性,6.1％的病人高敏,6％有代谢性耐受。对苯妥英钠的先天和代谢性耐受为2.7％,高敏者占8.1％。另外,本资料也显示病人对苯妥英钠和卡马西平的某些不良反应,存在着有益的功能性耐受。结合文献,本文对耐受性的分类、特征和可能的机理进行了复习。

In this paper, the tolerance to phenytoin (PHT) and carbmazeping (CBZ) were discussed in 327 epileptic patients based on monitoring the serum levels of these two antiepiteptic drugs. The result showed that with repeated administration of PHT and CBZ, their effectiveness was reduced. Patients acquired tolerance to PHT and CBZ. There were naturai, negative and metabolic tolerance.On the other hand, patients treated with PHT and CBZ showed clear evidence of developing beneficial tolerance to various side effects. With a review of literature, various forms of tolerance and their nature were discussed.