格林—巴利综合征患者血清中可溶性白细胞介素—2受体的测定

Serum concentration of soluble interleukin-2 receptors in GBS

本文采用ELISA双抗体夹心法对27例格林—巴利综合征患者血清中SIL—2R的含量进行了测定。结果显示本病患者急性期SIL—2R的含量较正常人明显升高,有显著性差异(P<0.001),病情危重者的SIL—2R含量虽较病情轻者升高,但无统计学意义。动态观察发现,在恢复期本病患者的SIL—2R的含量则有一定程度的降低。SIL—2R含量的升高,不仅提示本病患者的细胞免疫功能亢进,尤其T淋巴细胞处于激活状态,而且,对其发病机理的进一步认识,也有一定的临床意义。

Guillain-Barre Syndrome (GBS) is a disorder with presumed immunopathy. To obtain evidence for T cell activation, we determined serum concentration of soluble interleukin-2 receptors (SIL-2R) in 27 patients with GBS. The results showed that SIL-2R levels were markedly increased as compared with those in the control subjects and suggested that T cell are activated in GBS patients. SIL-2R concentration decreased with clinical improvement in serial samples taken from GBS patients, but not Correlated with disease severity.