匹布可罗宁和潘可罗宁临床应用的效果比较

Effective Comparison of Clinical USE of Pipecuronium and Pancuronium

本文观察对比临床应用匹布可罗宁与潘可罗宁的肌松情况及对血压脉搏之影响。选择一般情况相近似的两组病人,分别应用等效剂量的匹布可罗宁及潘可罗宁并记录各项肌松指标及血压、脉搏的变化。经统计学处理后潘可罗宁的恢复指数较匹布可罗宁显著延长(P<0.005)其余各肌松指标皆无显著性差异。两组病人在插管时血压均有显著增加,给药8min后恢复到给药前水平。两组肌松药对收缩压、舒张压、平均动脉压的影响均无显著性差异。只有心率变化两组不一致,潘可罗宁组在给药8min时仍高于给药前水平(P<0.002)。本研究提示在产生相同的肌松作用的前题下匹布可罗宁对循环系统影响小于潘可罗宁,蓄积程度也小。

Muscle relaxation and the influence on blood pressure and pulse rate have been observed clinically. General conditions were similar in two groups of patients Endotracheal intubation was performed after equivalent dose of pipecuronium or pancuronium given to each patient. Muscle relaxation index and blood pressure, pulse rate were recorded. Recovery index of pencuronium was significantly longer than that of pipecuronium(P<0.005) ,the other indexs had no any significant difference. Pulse rate hasa signifcant difference between the two groups(P<0.002). 8min after Ⅳ pancuronium the pulse rate was still faster than before. The results suggest that in equivalent dose,pipecuronium has less effect on the circulatory system than pan- cruonium and less accumulation than pancuronium.