肝硬化患者胆结石的发病率

Incidence of Gallstones with Cirrhosis Patients

本文回顾性总结近10年来住院肝硬化患者526例与非肝硬化者405例胆结石的发病情况,结果表明肝硬化组与非肝硬化组胆结石的发病率分别为11.22％和3.95％。两组比较差异显著(P<0.01)。其中胆色素结石占61.9％。其原因可能与肝脏对胆红素代谢异常和慢性溶血有关。肝硬化患者伴有黄疸为62.5％,但仅有25.4％的患者发现肝内外胆管结石。提示黄疸常常由于肝细胞损害所致。肝硬化伴胆结石无症状占66％,可能与胆囊结石发生率高有关。

A retrospective study of the prevalence of gallstones was performed in 526 patients with liver cirrhosis and in 405 controls. Gallstones were found more often in cirrhotic patients (11.22%) than in controls (3.95%) (P<0.01). 61.9% patients had bilirubinate stones. Possible explanations include bilirubinate metabolic changes in the liver and chronic hemolysis. The cirrhosis patients with jaundice was 62.5%, but only 25.4% patients had bil- iary tract stones which suggested that jaundice usually represents hepatocellular decompensa- tion, seldom indicating biliary obstruction.