格林—巴利综合征与空肠弯曲菌感染关系的初步探讨

A study on the relationship of Guillain-Barre syndrome and Campylobacter jejuni infection

采用Skirrow方法和固相酶联免疫吸附法分别对17例格林—巴利综合征病人、17例非格林—巴利综合征的神经系统疾病对照组及33例正常对照组的大便及血清行空肠弯曲菌培养及IgM、IgA、IgG抗体测定。结果显示:格林—巴利综合征病人中空肠弯曲菌的感染率,尤其是近期感染率明显高于对照组;其中,30岁以下及夏秋季节发病者的近期感染率高于30岁以上者及其它季节发病者。提示空肠弯曲菌感染可能是我国格林—巴利综合征的重要诱发因素之一。

Faecal culture for Campylobacter jejuni with the method of skirrow and serum class specific antibodies (IgG Ig/W IgA) to Campylobacter jejuni using a solid phase enzyme linked immunosorbent assay were performed in 17 cases of Guillain—Barre syndrome, 17 other neurologincal disease controls, and 33 normal contrels. The resutls revealed: 1. The incident of Campylobacter jejuni infection, especially the recent one in Gullain-Barre syndrome was much higher than in the other two groups. 2. The recent inCident of infection in those below 30- year old and those onset in the phase between summer and autumn were higher than those above 30—year old and those onset, in the other seasons. These indicated that Campylobacter jejuni infection may be one of the important causes, of Guiliain-Barre syndrome in China.