丙戊酸镁日剂量顿服疗法研究

Single dose therapy of magnesium valproate in epilepsy

本试验对34例癫痫病人进行了丙戊酸镁日剂量顿服疗法研究,并对其中11例进行了用药稳态后的12小时和24小时的血清VPA总浓度、脑脊液中丙戊酸镁浓度和血清中游离浓度的动态观察。结果表明:34例病人观察4个月后有效28例,有效率82.3％(癫痫发作频率减少62～100％)。以失神发作、原发性强直一阵挛发作效果最佳,对部分性发作效果较差。24小时的血药浓度均低于有效范围,但临床仍能维持其良好的效果,这可能与丙戊酸的延迟作用有关。

We have accomplished the study of single oral dose of magnesium valproate daily in 34 patients with epilepsy. We have also finished the drug concentration monitoring in plasma (bound and unbound) and cerebrospinal fluid in 11 of these patients. An average of 19.6mg/kg magnesium valproate per day was administered. Results indicated that frequency of paroxysms were significantly reduced (by 62-100%) in 28 patients (82.3%). Primary generalized tonicclonic fit and absence attack had more effect than partial seizures. The authors consider that the delayed effect of valproate is possibly concerned with its matabolites accumulation in the brain, which have also antiepileptic effect.