几种心血管病患者中性粒细胞氧化代谢的研究

Researches on PMN oxidative metabolism of patients with coronary heart disease and other cardiovascular heart diseases

本文以鲁米诺依赖的CL法检测83例不同心血管疾病患者外周血中性粒细胞的吞噬功能,并选择21例正常人作为对照。结果表明:①AMI组PMN-CL的本底、峰值、积分及吞噬指数均显著大于正常对照组(P均<0.001),也显著大于其他各组(P<0.05～0.001);②心绞痛组PMN-CL的本底、峰值、积分反吞噬指数显著大于正常对照组(P<0.01或0.001);与心肌炎、风心病组相比,PMN-CL的本底、吞噬指数显著增大(P<0.05～0.001)。③高血压心脏病组PMN-CL各项指标均显著大于正常对照组(P<0.01或O.001);同时显著小于AMI组(P均<0.05);与心绞痛组相比,PMN-CL各项指标无显著差异。④心肌炎组、风心病组与正常对照组相比,PMN-CL各项指标无差异。⑤各组间PMN-CL峰时无差异。文中就上述结果进行了讨论。

Polymorphonuclear leukocytes (PMN) produce active oxygen free radicals in phagocytosis, and company with chemiluminescence (CL), It was reported that the luminescence power was corresponded with the phagocytosis ability of PMN, Using whole blood luminol dependent CL.PMN-CL in 81 cases of four different cardiovascular diseases were detected.Including 35 cases of coronary heart disease (among them, 15 cases of AMI,20 cases of angina pectoris), 15 cases of hypertensive heart disease, 17 cases of acute viral myocarditis, 15 cases of rheumatic Cardiac valve disease,and 21 cases of normal subjects.The results showed that PMN CL parameters in AMI was signifficantly higher than that in other cardiovascular heart diseases and was also higher than that in normal subjects,The PMN-CL parameters in angina pectoris and hypertensive heart disease were signifficantly higher than that in normal group. The PMN-CL parameter had no signifficant diffferences between acute viral myocarditis, rheumatic cardiac valve disease and normal subjects, This indicates that oxygen free radicals produced by PMN play an important role in the process of AMI.