急性心肌梗塞患者神经内分泌的变化及开搏通对其影响

Study of the neuroendocrine changes and the effects of captopril in patients with AMI

对44例AMI患者的RAA进行检测,发现PRA、AⅡ、ALD及CA均明显高于对照组,且其浓度随着患者心功能损害的加重而逐渐升高。相关性分析显示:血浆CA变化与PRA、A Ⅱ、ALD密切相关,提示在AMI时血浆CA升高可能是激活RAA的因素之一。25例AMI患者服小剂量开搏通后,A Ⅱ、ALD、CA均明显下降(P<0.05～0.001),表明开搏通可改善AMI患者的神经内分泌状况。

In 44 patients with AMI changes of plasma renin activity (PRA) , concentrations of plasma angiotensin Ⅱ (A Ⅱ ) .plasma aldosterone (ALD)ancl plasma catecholamine(CA)were significantly higher than those of control group.and the changes of these indices gradually ascended with severity of heart dysfunction. The correlative analysis showed the changes of plasma CA were closely correlated with those of PRA.A Ⅱ and ALD. It indicated the changes of plasma CA during AMI may be one of factors to activate renin-angiotensin-aldosterone system. After small dose cap-topril therapy. In 25 patients with AMI A Ⅱ , ALD and CA decreased significantly (P<0. 05-0. 001). These data suggest captopril may turn over deteriorative neuroendocrine changes in patients with AMI.