原发性高血压家族史调查及遗传力估计

Family history investigation and heritability estimate in essential hypertension

对154例EH家族史进行病例对照调查。结果表明,EH组一级亲属高血压患病率(14.6％)约为对照组(2.7％)的5倍。先证者父亲的高血压患病率为男性先证者高于女性先证者,母亲的患病率则与之相反;男性先证者父亲高血压患病率高于其母亲患病率,而女性先证者则反之。高血压遗传力估计为73.5％。表明遗传因素在决定易患性变异上起着重要作用,遗传倾向具有明显的性别差异,与环境因素亦相关。

154 cases with the essetial hypertension (EH) family history were studied. The result shown the first relative invasion rate(14. 6%) of the EH group was 5 times as of the contrast group. The male patients were more than the female patients in respect of the hypertension invasion rate of the patient's father. The female patients were more than the male patients in respect of the hypertension invasion rate of the patient's mother. The hypertension invasion rate of father was higher than that of mother in the male patient. The hypertension invasion rate of the mother was higher than that of mother in the male patient. The hypertension invasion rate of the mother was higher than that of father in the female patient. The hypertension heritability was about 73. 6%. There was significant difference between male and female in genetic predisposition.