开博通对高血压病患者左室舒张及收缩功能的影响

The effect of captopril on left ventricular diastolic and systolic function in the patients with hypertension

开博通治疗30例Ⅱ期及32例Ⅲ期高血压病患者,降压有效率分别为73.3％、59.4％,总有效率66.1％,无则显副作用。41例患者维持有效降压治疗3～4月(平均101天)。以多普勒超声检测评估左室功能,结果显示治疗后其减退的左室舒张功能明显改善,降低的左室收缩功能显著提高(P<0.05或P<0.01),对正常的收缩功能则无影响。

Sixty-two patients with hypertension were treated by captopril. The results showed that the elevated arterial pressure was significantly decreased in forty-one of them (66%) after treatment. Their blood pressure was attenuated to 18. 14±1. 95/11. 76±1. 31 kPa (136. 2 ± 14.1/ 88. 2±9. 8 mmHg)from 21. 08±1. 69/12. 76±0. 71 kPa(158. 1±12. 7/95. 7±5. 3 mmHg).and there were few side-effects. At the end of treatment period for 101 days.peak velocity at rapid filling (E) and the ratio of E to peak velocity at artrial contraction were significantly increased in all patients with damaged left ventricular diastolic function (P<0. 05 or P<0. 01) ;preejection period to left ventricular ejection time (P/L) was dereased ,peak flow velocity (PFV)and flow velocity in-tergration(FVdI) significantly raised (P<0. 05 or P<0. 01) in twenty-one patients with decreased left ventricular systolic function,but no significant difference was found in twenty patients with normal systolic function,compared with the values before treatment.It is concluded that captopril can significantly attenuate the elevated arterial pressure,and improve the damaged left ventricular diastolic and systolic function,but does not effect the normal systolic function in patients with hypertension.