高血压病患者的胰岛素抵抗现象初探

Insulin resistance in essential hypertension

报告在作葡萄糖(G)耐量试验的同时,测定血胰岛素(In)的变化,对26例高血压病(EH)患者与24例健康人进行比较观察,见两组空腹血糖和糖耐量无差异,而EH组空腹及糖负荷后的血In水平以及In/G比值等指标均高于对照组(NT)(P<0.001),表明EH患者存在In抵抗现象。

Insulin resistance(IR) in 26 essential hypertension patients(18 non-obese, 8 obese) was studied and compared with 24 normotensive(NT)subjects. The results showed that: the fasting plasma insulin levels and insulin glucose ratio.the plasma insulin levels and(AUC)1n during intravenous glucose tolerance test were higher in hypertensive patients than those in NT subjects. These differences were more significant in obese patients than in non-obese patients. However,the correlation between plasma insulin levels and blood pressurs was more significant in non-obese patients than in obese patients. The plasma glucose levels either in fasting or after glucose load in hypertensive patients were not significantly different from those in NT subjects. This study strongly suggests that insulin resistance is a characteristic feature and an important metabolic disturbance of es sential hypertension independent of obesity.