软组织恶性纤维组织细胞瘤60例临床病理分析

Clinicopathologic Analysis of 60 Cases of Malignant Fibrous Histiocytoma of Soft Tissue

本文报道60例软组织恶性纤维组织细胞瘤的临床病理资料。肿瘤发生以大腿、肩和腹部为主,平均年龄41～50岁,以成人为主。肿块直径平均为5cm。肿瘤侵入于皮下层(12/60),扩展列深筋膜(33/60)和肌层(15/60),分别为20%、55%和25%。病理形态多变,以席纹—多形型占多数60.0%(36/60)。局部发生率44.4%(16/36)。多数转移列肺,其转移率为13.9%(5/36)。患者1、2和5年生存率分别为78.4%(40/51)、62.2%(28/45)和33.3%(12/36)。影响预后的因素为肿瘤深度和组织学类型。

The clinicopathologic analysis of 60 cases malignant fibrous histiocytoma(MFH)of softtissue were presented.This tumor occured principally on the thigh,shoulder and abdomen of adults(peak incidence 41～50 years of age).The median size of the mass was 5 cm.It confined to the sub-cutis,involved to the deep fascia,skeletal and muscle with 20%,55%,and 25%,respectively.TheMFH had variable morphologic feature.The most histologic pattern was storiform-pleomorphic(59.9%,36/60 cases).The local recurrence rate was 44.4%(16/36 cases).The tumor matastasizedfreguently to the lung(13.9%,5/36 cases).The 1,2 and 5 year survival rate were 78.4%(40/51),62.2%(28/45)and 33.3%(12/36),respectively.The prognostic factors were related to thedepth and histologic pattern of the MFH.