成人急性淋巴细胞白血病的免疫标记诊断与疗效观察

Immunophenotypic Diagnosis of Adult Acute Lymphoid Leukemia and the Therapeutic Effect

本文报告了65例成人急性淋巴细胞白血病的免疫标记诊断结果。按其表面抗原的表达,分为4个亚型:C-,T-,N-,B-ALL。发病情况依次为43.1%,29.20%,15.4%,12.3%。观察了本组各亚型临床治疗疗效,以B-ALL的CR率最低,难治性病例最多。作者认为,急性白血病的免疫表型分析,有助于诊断和预后判断。应根据免疫分型诊断,调整B-ALL化疗方案;可改善B-ALL的预后。

Immunophenotypical analysis was porformed in 65 patients with acute lymphoid leukemia (ALL). According to immunophenotype of ALL, A Subtypes were as follows: C-,T-, B-ALL. The incidance of each subtype was 43.1%, 29.2%, 15.4%, 12.3%, respectively. Meanwhile, the clinical efficiency of chemotherapy was observed in each subtype of which,the complete remission (CR) rate in patients with B-ALL was the lowest; in contrast, with refractory characteristics the most predominant. It is concluded that immunophenotypic analysis of ALL was helpful not only to the diagnosis of various subtypes, but also to the determination of prognosis. In addition, it is likely that it will improve the prognosis of patients with B-ALL to adapt individually chemotherapy regimens basing upon the diagnosis from immunophenotypic labelling.