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咪唑斯汀治疗荨麻疹多中心临床研究 被引量:1

A Multicenter, Open, Non - controlled Clinicai Study on Mizolastine for the Treatment ofChred Ma
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摘要 目的:观察咪唑斯汀治疗慢性荨麻疹的临床疗效的安全性。方法:采用多中心、开放、临床研究方法,人选病例每日日服一片咪唑斯汀(每片10mg),疗程为14d。结果:共治疗858例,其中男400例,女458例。用药后第7 d的有效率为 85.1%,第 14 d的有效率为 95.0%。药物不良反应较轻,发生率为4.1%。结论:咪唑斯汀是一种治疗慢性荨麻疹安全有效的药物。 To observe the clinical efficacy and safety of mizolastine in the treatment ofchronic urticaria. Methods: A multicenter, open, clinical study was conducted. The patients withchronic urticaria applied orally a tablet of mizolastine (20 mg per tablet) daily for 14 days. Results: Atotal of 858 patients with chronic urticaria were treated, of which 400 cases were male, 458 were fe-male. The effective rate was 85. 1 % by one week treatment, and 95 .0% by two weeks treatment. Theadverse reaction was mild, the occurrence rate was 4. 1 %. Conclusion: Mizolastine is a sdfe and effec-tive agent in the treatment of chronic urticaria.
出处 《岭南皮肤性病科杂志》 2002年第1期13-15,共3页 Southern China Journal of Dermato-Venereology
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  • 1Brostoff J, Fitzharis P, Dunmore C, et al. Efficacy of mizolastine, a new antihistamine, compared with placebo in the treatment of chronic idiopathic urticaria. Allergy, 1996, 51 (5):320 - 325.
  • 2Dubertret L, Murrieta Aguttes M, Tonet J. Efficacy and safety of mizolastine 10 mg in a placebo - controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILORstudy. J Eur Acad Dermatol Venereol, 1999, 12( 1 ): 16 - 24.
  • 3Slater JW, Zechnich AD, Haxby DG. Second - generation antihistamines: a comparative review. Drugs, 1999, 57(1): 31-47.
  • 4Horak F, Stubner UP. Comparative tolerability of second generation antihistamines. Drug Saf, 1999, 20(5): 385 - 401.

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