摘要
Severe acute respiratory syndrome (SARS) is a serious and fatal infectious disease caused by SARS coronavirus(SARS-Cov),a novel human coronavirus.SARS-Cov infection stimulates cytokines (e.g.,IL-10, IFN-γ,IL-1,etc.)expression dramatically,and T lymphocytes and their subsets CD4^+ and CD8^+ T cells are decreased after onset of the disease.SARS-specific IgG antibody is generated in the second week and persists for a long time,whereas IgM is expressed transiently.The spike protein and neucleocapsid protein are most abundant in SARS-Cov and contribute dominantly to the antibody production during the course of disease. Spike protein,especially the ACE-2 binding region(318-510aa)is capable of producing neutralizing antibody to SARS-Cov.Neucleocapsid protein induces protective specific CTL to SARS-Cov.Therefore,applications with spike subunit,neucleocapsid subunit as well as inactivated SARS-Cov are three prospective vaccination strategies for SARS.Cellular & Molecular Immunology.2004;1(3):193-198.
Severe acute respiratory syndrome (SARS) is a serious and fatal infectious disease caused by SARS coronavirus(SARS-Cov),a novel human coronavirus.SARS-Cov infection stimulates cytokines (e.g.,IL-10, IFN-γ,IL-1,etc.)expression dramatically,and T lymphocytes and their subsets CD4^+ and CD8^+ T cells are decreased after onset of the disease.SARS-specific IgG antibody is generated in the second week and persists for a long time,whereas IgM is expressed transiently.The spike protein and neucleocapsid protein are most abundant in SARS-Cov and contribute dominantly to the antibody production during the course of disease. Spike protein,especially the ACE-2 binding region(318-510aa)is capable of producing neutralizing antibody to SARS-Cov.Neucleocapsid protein induces protective specific CTL to SARS-Cov.Therefore,applications with spike subunit,neucleocapsid subunit as well as inactivated SARS-Cov are three prospective vaccination strategies for SARS.Cellular & Molecular Immunology.2004;1(3):193-198.
