手性固定相上对新型手性四面体簇合物的高效液相色谱手性拆分

Enantioseparation of Novel Chiral Tetrahedral Clusters on a Chiral Stationary Phase (CSP) by High Performance Liquid Chromatography

In recent years, the synthesis of chiral tetrahedral clusters has been studied extensively and various types are accessible[1,2], which are a kind of organometallic compounds with greatly growing interest due to their potential application to asymmetric reaction catalysts[3,4]. As an efficient separation technique for enantioseparation which requires mild separation conditions, high performance liquid chromatography (HPLC) is considered to be the most efficient way to resolve the clusters with new-type chiral stationary phases (CSPs) without destruction of the clusters. In the present work, a new CSP was prepared by coating amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) on small particle silica gel, and for the first time applied to the enantioseparation of some new chiral tetrahedral clusters with good results. The effects of various parameters on the retention factors and separation results were also investigated.