急性脑梗塞伴急性肺损害时肺内毒素受体CD_(14)基因的表达

The Gene Expression of Endotoxin Receptor CD_(14) in Acute Cerebral Infarction Accompanied by Acute Lung Injury

目的 :探讨急性脑梗塞伴肺损害时肺内毒素受体 CD1 4m RNA的表达 ,观察其变化规律与肺损害的关系。方法 :选择急性脑梗塞伴肺损害 87例、急性脑梗塞不伴肺损害 86例、健康对照组 6 0例 ,进行肺组织内毒素 CD1 4m RNA的检测。观察 3组 (12、2 4、36、4 8、72 h)肺内毒素受体 CD1 4m RNA的表达。结果 :1脑梗塞伴肺损害组 12 h肺组织 CD1 4m RNA表达开始升高 ,2 4～ 36 h CD1 4m RNA达高峰 ,72 h后下降 ,各时相点与脑梗塞不伴肺损害组比较有显著差异 (P<0 .0 1) ;2脑梗塞伴肺损害组与健康对照组比较有极显著差异 (P<0 .0 0 1) ;3脑梗塞不伴肺损害组与健康对照组比较有差异 (P<0 .0 5 )。结论 :急性脑梗塞伴肺损害时肺组织内毒素受体 CD1 4m RNA的异常表达 ,是导致急性肺损害的危险因素 ,也是导致多脏器功能障碍的重要危险因素。

Objective:To investigate the expression of endotoxin receptor CD 14 in acute cerebral infarction accompanied by acute lung injury and to observe the relationship between the changing trend and lung injuryMetheds:87 patients with acute cerebral infarction accompanied acute lung injury,86 patients unaccompanied lung injury ,and 60 healthy persons were collectedand the expression of endotoxin receptor CD 14 mRNA in lung was determined .Results:①In cerebral infarction accompanied by lung injury group the CD 14 mRNA expression in lung tissues increased after 12h,and reached the peak at 24～36 h,and decreased after 72h . There were significant difference of CD 14 mRNA expression at each time point compared with cerebral infarction unaccompanied by lung injury group (P<0.01);②There were significant difference between the cerebral infarction accompanied by lung injury group and the control group (P<0.001);there were difference between the cerbral infarction unaccompanied by lung injury group and the control group (P< 0.05) .Conclusions:Abnormal expression of endotoxin receptor CD 14 of acute cerebral infarction a ccompanied by acute lung injury could be an importent damgerous factor leading to acute lung injury can multiple organ dysfunction.