原发性肝癌凝血功能变化的临床价值

Clinical Value of Coagulation Parameters in Patients with Primary Hepatic Carcinoma

目的 :探讨原发性肝癌患者凝血功能变化情况及其临床价值。方法 :对原发性肝癌 6 0例进行凝血酶原时间 (PT)、活化部分凝血酶原时间 (APTT)、纤维蛋白原 (FIB)、凝血酶时间 (TT) 4项凝血指标进行检测和对比分析。结果 :原发性肝癌组与对照组相比 ,PT、APTT、TT均显著延长 P<0 .0 1,FIB明显降低 P<0 .0 5 ,肝癌并发症组与无并发症组相比 ,PT、APTT均显著延长 P<0 .0 1,P<0 .0 5 ,FIB显著降低 P<0 .0 1;原发性肝癌转移组与无转移组相比 ,PT、APTT明显延长 P<0 .0 5 ,FIB显著降低 P<0 .0 5。不同肝功能分级检测结果显示 PT、APTT和 FIB有显著差别。结论 :原发性肝癌患者可出现凝血功能障碍 ,而凝血功能变化情况对评估肝癌肝损害的程度、监测病情变化 ,指导临床治疗及其预后具有一定的应用价值。

Objective:To investigate the clinical value of coagulation parameters in patients with primary hepatic carcinoma.Methods:To examine and compare the levels of Prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT) in 40 patients with primary hepatic carcinoma.Results:The levels of PT,APTT,TT were significantly prolonged ,whereas the FIB was markedly reduced in patients with primary hepatic carcinoma than those in controls. Moreover,PT,APTT notably prolonged,but FIB reduced significantly in patients comparing complication of hepatic carcinoma with those simplication. Comparing metastasis carcinoma with preinvasive carcinoma,PT,APTT prolonged,and FIB reduced significantly. The values of PT、APTT and FIB were significantly different according to different grades of liver function.Conclusion:The results showed the decrease of coagulability in primary hepatic carcinoma patients. These markers were useful to evaluate liver damage,to predict complication and metastasis ,and to estimate prognosis.