摘要
利用 1 苯基 3 甲基 4 苯甲酰基 5 吡唑啉酮 (PMBP)和对氨基苯乙酮 (PAAP)制备了PMBP缩对氨基苯乙酮 (PMBP缩PAAP)及其铜 (II)、钴 (II)、镍 (II)和锌 (II)配合物 ,根据元素分析、红外、紫外、MS和1HNMR谱表征了结构 .利用量子化学和分子力学计算方法对缩合反应的机理进行了探讨 ,较好地解释了PMBP PAAP配体的烯胺酮式构型及其配合物的亚胺烯醇式构型 .测定了化合物对大肠杆菌和金黄色葡萄球菌的抑制活性 ,其中以钴 (II)和铜配合物 (II)
The ligand prepared from PMBP with p-aminoacetophenone and its Cu(II), Co(II), Ni(II) and Zn(II) complexes have been synthesized and characterized by IR, UV, MS and H-1 NMR spectra. The mechanism of the condensed reaction has been discussed using quantum chemistry and molecular mechanics calculation, which can explain the enamine conformation of the ligand and the imine-enol conformation of the complexes. The antibacterial activities have been screened for these compounds, among which the Co(II) and Cu(II) complexes have the most intense antibacterial activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第11期1423-1428,共6页
Chinese Journal of Organic Chemistry
基金
天津市科委自然基金 (No.0 0 360 1 71 1 )
天津理工学院科技发展基金 (No.LG0 30 2 1 )资助项目