摘要
以芳醛、丙二腈和 7 甲氧基 1,2 ,3 ,4 四氢萘 2 酮为原料 ,在六氢吡啶催化下以乙醇为溶剂 ,在室温合成了一系列新的 2 氨基 3 氰基 4 芳基 6 甲氧基 1,4,9,10 四氢萘并 [2 ,1 b]吡喃衍生物 ,反应条件温和 ,产率较高 ,并通过IR ,1HNMR和元素分析表征产物的结构 。
Using piperidine as catalyst and ethanol as solvent, a series of new 2-amino-3-eyano-4-aryl-6-methoxy-1,4,9, 10-tetrahydronaphtho [2,1- b] pyran derivatives were synthesized by one-pot reaction of aromatic aldehydes, malononitrile and 7-methoxy-1, 2, 3, 4-tetrahydronaphthalen-2-one at room temperature in good yields. The reaction conditions were mild. The structures of the products were characterized by IR, H-1 NMR spectra and elemental analysis. The conformation of compound 4a was also confirmed by X-ray analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第11期1454-1457,共4页
Chinese Journal of Organic Chemistry
基金
江苏省青蓝工程基金 (No.QL980 0 1 )
江苏省教育厅高校自然科学基金 (No.0 2KJB1 50 1 39)资助项目