2-氨基-3-氰基-4-芳基-6-甲氧基-1,4,9,10-四氢萘并[2,1-b]吡喃衍生物的一步合成

One-Step Synthesis of 2-Amino-3-cyano-4-aryl-6-methoxy-1,4,9,10- tetrahydronaphtho[2,1-b]pyran Derivatives

以芳醛、丙二腈和 7 甲氧基 1,2 ,3 ,4 四氢萘 2 酮为原料 ,在六氢吡啶催化下以乙醇为溶剂 ,在室温合成了一系列新的 2 氨基 3 氰基 4 芳基 6 甲氧基 1,4,9,10 四氢萘并 [2 ,1 b]吡喃衍生物 ,反应条件温和 ,产率较高 ,并通过IR ,1HNMR和元素分析表征产物的结构 。

Using piperidine as catalyst and ethanol as solvent, a series of new 2-amino-3-eyano-4-aryl-6-methoxy-1,4,9, 10-tetrahydronaphtho [2,1- b] pyran derivatives were synthesized by one-pot reaction of aromatic aldehydes, malononitrile and 7-methoxy-1, 2, 3, 4-tetrahydronaphthalen-2-one at room temperature in good yields. The reaction conditions were mild. The structures of the products were characterized by IR, H-1 NMR spectra and elemental analysis. The conformation of compound 4a was also confirmed by X-ray analysis.