新型卤代羟基三苯醚的合成与抑菌活性研究

Synthesis and Antimicrobial Activities of Halogenated Hydroxy Triphenyl Ethers

设计合成了对 (间、邻 )苯二酚二 ( 4 氯 2 羟基苯基 )醚 ( 4a～ 4c)及对 (间、邻 )苯二酚二 ( 4 氯 5 溴 2 羟基苯基 )醚( 5a～ 5c)共 6个卤代羟基三苯醚类化合物 ,其结构均经1HNMR ,IR ,MS和元素分析证实 ,并且对其抑菌活性进行了初步测试 .结果表明 :此类化合物大多在低浓度下对大肠杆菌、金黄色葡萄球菌、白色念珠菌、白色葡萄球菌、变形杆菌、卡他双球菌。

p ( rn, o) -Benzenediol di (4-chloro-2-hydroxyphenyl) ethers (4a similar to 4c) and p ( m, o) -benzenediol di (4chlorx)-5-bromo-2-hydroxyphenyl) ethers (5a similar to 5c) were synthesized, and their structures were characterized by H-1 NMR, IR, MS spectra and elemental analysis. Their antimicrobial activities were investigated, and the preliminary results indicate that they have good antimicrobial activities on Escherichia coli ( E. coli), Staphylococcus aureaus (S. aureus), Candida albicans ( C. albicans), Staphylococcus albus ( S. albus Proteus vulgaris ( P. vulgaris), Diplococcus catarrhalis (D. cata), Pseudornona ssolanaceanan (P. solanacearum).