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猪用生长激素(PST)脂质体生物学稳定性及促生长生物活性的研究 被引量：1

Studies on the Stability in Vitro and Growth Enhancing Activity of PST Liposomes
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摘要 本文着重对PST脂质体体外稳定性进行研究 ,试验表明 :PST脂质体在猪血浆中稳定性较好。对大白鼠促生长效应实验结果表明 :PST和PST脂质体对大白鼠具有促生长活性。试验组与对照组之间差异显著 (P <0 .0 5 ) ,PST脂质体具有显著的缓释作用 ,缓释期可达 The test on PST liposomes stability in vitro showed that the stability of PST liposomes was good in pig-s plasma.The outcome of PST liposomes activity of growth enhancement in rat manifested that PST and PST liposomes promoted rat growth.The difference between treatment group and control group was obvious.PST liposomes had great sustained-release effect,which could last more than seven days.
作者 胥传来 姚惠源
机构地区 江南大学食品学院
出处 《中国粮油学报》 EI CAS CSCD 北大核心 2004年第5期79-82,共4页 Journal of the Chinese Cereals and Oils Association
关键词 促生长效应 PST脂质体 猪血浆 试验 缓释作用 生长激素 体外稳定性 对照组 生物活性 大白鼠 stability,growth enhancing activity,liposomes
分类号 TS192.29 [轻工技术与工程—纺织化学与染整工程] S859 [农业科学—临床兽医学]
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参考文献3

  • 1Devine DV,-Wong K,et al.liposome-complement interactions in rat serum:implications for liposome survival studies.Biochim Biophys Acta,1994,1191:43-51
  • 2Wolverton,C.K.M.J.Azain.J.Y.Duffy,M.E.White and T.G.Ramsay.1992.Influence of somatotropin on lipid metabolism and IGF-I gene expressionin porcine adipose tissue.Am.J.Physiol.E637-E645
  • 3Baxter JB,Blalock JE,Weigent DA,Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone.Endocrinology 1991,129:1727-1734

同被引文献22

  • 1于维萍,牟晓莹,孙萍.脂质体不同给药系统的研究[J].齐鲁药事,2004,23(6):36-38. 被引量：6
  • 2于芝颖,张海英,张华,张强,李玉珍.重组人生长激素聚乙交酯-丙交酯微球体外释放度研究[J].中国药学杂志,2004,39(8):608-611. 被引量：4
  • 3Takada S,Yamagata Y.Sustained release of human growth hormone from microcapsules prepared by a solvent evaporation technique[J].Journal of Controlled Release 2003,88:229-242.
  • 4Putney S D,Burke P A,Improving protein therapeutics with sustained-release formulations,Nat Biotechnol.1998,16 (5):153-157.
  • 5Kim H K,Park T G,Microencapsulation of dissociable human growth hormone aggregates within poly(DL-lactic-co-glycolic acid) microparticles for sustained release[J].Int J Pharm,2001,22 (9):107-116.
  • 6Kim H K,Park T G,Comparative study on sustained release of human growth hormone from semi-crystalline poly(L-lactic acid) and amorphous poly(D,L-lactic-co-glycolic acid) microspheres:morphologicaleffect on protein release[J].Journal of Controlled Release,2004,98 (10):115-125.
  • 7Cleland J L,Olu Funmi L.Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development[J].Advanced Drug Delivery Reviews,1997,28 (6):71-84.
  • 8Johnson O L,Jaworowicz W,Cleland J L,et al.The stabilization and encapsulation of human growth hormone into biodegradable microspheres[J].Pharm Res,1997,14 (6):1824-1835.
  • 9Cleland J L,Jones A J S.Stable formulations of recombinant human growth hormone and interferong for microen-recapsulation in biodegradable polymers[J].Pharm Res,1996,13(9):1462-1473.
  • 10Kim S J,Hahn S K,Kim M J,et al.Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles[J].Journal of Controlled Release,1997,49(5):193-205.

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中国粮油学报
2004年 第5期

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