65例亚胺培南/西司他丁药品不良反应分析

Adverse Reactions due to Imipenem/cilastatin:A 65 Case Analysis

目的 进一步了解近年来亚胺培南 /西司他丁的用药安全性 ,为临床合理使用亚胺培南 /西司他丁提供依据。方法 对全军药品不良反应 (ADR)监测中心数据库中亚胺培南 /西司他丁的药品不良反应病例进行数据分析 ,重点分析发生不良反应的患者年龄、临床表现、用药合理性等。结果 近年来 ,亚胺培南 /西司他丁的不良反应发生率有所上升 ,且不良反应涉及系统较广 ,并且临床用药中存在一定问题。结论 虽然亚胺培南 /西司他丁的药理作用人所共识 ,但临床用药还应当从多个角度出发 ,做到合理用药 。

OBJECTIVE To comprehend the security of imipenem/cilastatin more and supply the gist of reasonable use for clinic. METHODS The data of imipenem/cilastatin′s adverse reaction from the data base of the PLA Center for ADRs Monitoring were used to analyze the age of ADR sufferers, their ADR representation, the rationality of clinic use of medicine etc. RESULTS There were more and more adverse reactions due to imipenem/cilastatin during recent years,and the suffered systems were very broad,at the same time we found many problems in the course of drug use. CONCLUSIONS Although imipenem/cilastatin′s clinical usage is knowable,we must think much of their use, to use them more reasonably, and to avoid their adverse reaction.