基层医院产超广谱β-内酰胺酶菌株感染的调查

Infection of Extended-spectrum β-Lactamases Producing Strains in Primary Hospital

目的 监测基层医院超广谱 β 内酰胺酶 (ESBLs)菌株的感染和耐药现状 ,以指导临床医师的合理用药。方法 采用双纸片协同法初筛 ,确证法检测ESBLs菌株 ,并对筛选确证为产ESBLs菌株进行药敏试验。结果 产ESBLs菌株共 4 4株 ,均为大肠埃希菌和肺炎克雷伯菌 ,它们对多种抗生素显示耐药 ,仅亚胺培南敏感率为 10 0 %。结论 基层医院也存在ESBLs菌株感染 ,细菌室应注重ESBLs的监测和报告 ,指导临床合理应用抗生素 。

OBJECTIVE To evaluate infection and drug resistance status of extended spectrum β lactamases (ESBLs) producing strains in primary hospital. METHODS ESBLs strains were screened by double disk synergy test and detected by confirmatory test. Drug resistance test was then performed. RESULTS Forty four ESBLs producing strains were detected. They were Escherichia coli and Klebsiella pneumoniae. They showed great drug resistance trend, but were still sensitive to imipenem (100%). CONCLUSIONS ESBLs producing strains are also encountered in primary hospitals. The microbiology laboratory should pay heed to its detection for rational use of antibiotics and effective control of resistance.