心房颤动患者血清一氧化氮水平和血小板活化

Study on serum levels of nitric oxide and activation of platelet in patients with atrial fibrillation

目的观察慢性心房颤动(atrialfibrillation,Af)患者血清一氧化氮(NO)水平和血小板活化的异常及其临床意义。方法测量17例风湿性瓣膜病伴Af患者,12例非瓣膜病伴Af患者和13例窦性心律对照组血清NO水平、血浆平均血小板体积(MPV)和纤维蛋白原(Fg)浓度。结果与窦性心律相比,Af患者血清NO浓度极显著下降(78.30±37.06VS110.24±55.36umol/L,P<0.01)而血浆MPV则明显升高(12.13±1.68VS10.03±1.21f1,P<0.05),Fg轻度升高但无显著性差异(3.03±0.90VS3.41±1.40g/L,P>0.05)。瓣膜病伴Af组与非瓣膜病伴Af组二者之间NO,MPV和Fg水平无显著差异(P>0.05)。结论心房颤动患者外周血存在血小板活化和一氧化氮水平降低,这可能与房颤易于形成血栓有关。

objective:To observe serum levels of nitric oxide(NO)and activation of platelet and their clinical sig-nificance in patients with chronic atrial fibrillation(Af).Methods:Serum levels of nitric oxide(NO),mean platelet volume(MPV),fibrinogen(Fg)were measured from29patients with Af or13healthy subjects.These patients were divided into sinus rhythm(SR)group and Af group.Results:Compared with SR,patients with Af had lower serum levels of NO[(78.30±37.06)vs(110.24±55.36)μmol/L,P<0.01],and higher plasma levels of MPV[(12.13±1.68)vs(10.03±1.21)fl,P<0.05].NO significant differences were found in Fg between Af and SR[(3.03±0.90)vs(3.41±1.40)g/L,P>0.05].No significant differences were found in NO,MPV,Fg between Af with valvular heart disease and Af with non-valvular heart disease(P>0.05).Conclusions:Af shows activation of platelet and decreases of NO level.This may contribute to increase risk of thrombosis.