不同方法受孕双胎妊娠结局的临床分析

Analysis of perinatal outcomes of twin pregnancies conceived by different ways

目的探讨辅助生育技术受孕与自然受孕两种不同方法受孕双胎妊娠围产期的结局。方法回顾性分析110例辅助生育技术受孕双胎孕妇(助孕组)和175例自然受孕双胎孕妇(自然受孕组)病例。结果助孕组平均年龄(33.2±2.6)岁、早产73例(66.4%),明显高于自然受孕组年龄(28.1±3.1)岁、早产77例(44.0%),差异均有极显著性(P<0.01);助孕组妊高征40例(36.4%)、剖宫产82例(74.5%),与自然受孕组妊高征86例(49.1%)、剖宫产105例(60.0%)之间差异均有显著性(P<0.05);两组围产儿并发症差异无显著性(P>0.05),自然受孕组双胎之一胎儿宫内死亡明显高于助孕组(P<0.01)。结论助孕双胎孕妇年龄较大,早产率发生率高,分娩方式以剖宫产为主。自然受孕组易发生双胎之一胎儿宫内死亡,两组围产儿结局相似。

Objective:To investigate perinatal outcomes of twin pregnancies conceived by assisted reproductive techniques and those conceived spontaneously.Methods:110twin pregnancies conceived by assisted reproductive techniques and175spontaneous ones were analyzed retrospectively.Results:The women of twin pregnancies con-ceived by assisted reproductive techniques were(33.2±2.6)years old,in which73women were premature delivery(66.4%);while the spontaneous ones were(28.1±3.1)years old,in which77women were premature delivery(44.0%).There was significant difference between two groups(P <0.01).There were40cases(36.4%)preeclampsia and82cases(74.5%)cesarean sections in assisted reproduction group,while86cases(49.1%)preeclampsia and105(60.0%)cases cesarean sections in spontaneous group.There were also significant differences between the two groups(P <0.05).There were no statistically significant differences in prenatal morbidity between two groups(P >0.05).The incidence of one fetal death in spontaneous groups was significant higher than that of assisted reproduc-tion group(P <0.01).Conclusion:The women of twin pregnancies conceived by assisted reproductive techniques are older than those conceived spontaneously.The incidence of premature delivery and cesarean section were higher in assisted reproduction group,while the incidence of one fetal death is higher in spontaneous group.No statistically significant differences in perinatal morbidity are found between the two groups.